Thank you for your message! In the book the amounts are so small that you have to dilute the venlafaxine for the last dosage . The smaller dose, the longer time in between dose changes. A copy of this book should be in every GP surgery. They happily prescribe these drugs, and yet it seems that many/most understand nothing about the safest way to deprescribe these medications. The thing that annoys me most, is not the fact that my doctor has no experience in this situation, but that she appears to have made no effort whatsoever, to educate herself about the subject in the past year! To say that I am disappointed in this is an understatement.