Hans, If you read this entire article and understood all the complex enzymatic processes being analyzed, you don’t belong on this forum….you belong in the front of a lecture hall of PhD candidates at a prestigious institute!😂
But seriously, I don’t think they were speaking to your situation as it is right now. They seem to be trying to understand why BAT therapy - switching between periods of ADT/no ADT and in some cases low doses of androgens (T) - works or doesn’t.
They talk about early and late stage AR signaling and how that might be useful and harnessed during BAT therapy to increase its efficacy. At least, that’s my take.
But again, this is something you may never have to worry about. I know you are concerned that your tumor grew in a low T environment, and that ADT might make it worse; however, science still doesn’t know for sure how much T is too much or too little - only castrate levels! Similarly, the genetic make-up of your cancer cells might make them able to proliferate at lower than normal levels of T.
That does NOT mean that your low androgen level CAUSED it to grow - in fact, it probably means that you need a longer time on ADT to eradicate it.