I haven't tried FD Gard because it is somewhat expensive and only lists symptoms like nausea, bloating, and early fullness. But I have tried different herbs like Artichoke extract and Lemon Balm Oil. Desipramine was prescribed by a GI dr. though I haven't found it nor anything that works yet. An ice pack is slightly helpful, but not always possible. I wish you well in your search for relief and comfort.