That was a question that I asked my neurologist after being seizure free for over 30 years. He said that yes, that plays a role in seizures reappearing. I also learned by my neurologist the estrogen affects the medication that I was taking, therefore making the threshold very low for having seizures. Then, of course when factoring stress, environmental issues, and other factors, and it can make for an unfortunate situations. Also things like hormonal changes, particularly in women, when reaching menopause, post menopause, etc. these were all things that my doctor was able to pinpoint when I gave him the entire history of the time periods of which I had seizures, and then the long length of time that I had none at all, and that they were controlled, and then after I had been attacked and suffered a brain injury, then they started back up again. He was able to pinpoint correlations as to when, my body changed, and when the brain suffered injuries, and then having to go down that path of trying all different kinds of medications to control the situation, however, even years after this has happened, I am now having them in my sleep, whereas I didn’t used to have them in my sleep before. I’m not sure why that is happening. The medication protects me during the day but in my sleep it does not. Does anyone else have this issue?