1. < Osteoporosis & Bone Health

Transdermal HRT

Posted by vkmov @vkmov, Oct 19, 2023

Many studies have found that transdermal HRT protects and builds bone without all the horrific side effects of many first-line osteoporosis treatments. The patch bypasses the liver and thereby avoids the risks of breast cancer, strokes, etc. Has anyone explored this or discussed it with their doctors?

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gravity3 | @gravity3 | 8 hours ago
In reply to @gravity3 "I have had a hysterectomy. My cocktail includes estradiol patch currently .0375 but will go up..." + (show)
@gravity3

I have had a hysterectomy.
My cocktail includes estradiol patch currently .0375 but will go up a bit more, progesterone, testosterone pellet and estradiol cream to be used vaginally.
Yes, less brain fog, more grounded, terrific increase in libido.

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She started me on.025 estradiol patch be cause I had not had any hrt treatment decades.

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vkmov | @vkmov | 2 hours ago
In reply to @mayblin "I just realized and wanted to add some more info. You probably know that micronized progesterone..." + (show)
@mayblin

I just realized and wanted to add some more info. You probably know that micronized progesterone is added to the mix of E2 for those who still have a uterus to minimized the risk of uterine lining hyperplasia. Your obgyn would know if you need progeterone in your case.

This link which @gently provided is very useful in that it's a compilation of users' data for women older than 65:
https://journals.lww.com/menopausejournal/fulltext/2024/05000/use_of_menopausal_hormone_therapy_beyond_age_65.3.aspx
Table 3 and 4 summarized risk reduction or increase based on:
Estrogen alone
Estrogen + progestin
Estrogen + progesterone
Then by type of Estrogen, route and dose.

If one uses E2 alone, the adjusted hazard ratio looks very favorable in many risk categories. Hope these info are somewhat useful to you also if you haven't read them.

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SO helpful. Thank you so much!

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vkmov | @vkmov | 2 hours ago
In reply to @drsuefowler "@mayblin, I'm glad you were able to get the evaluations you needed to safely take estrogen...." + (show)
@drsuefowler

@mayblin,

I'm glad you were able to get the evaluations you needed to safely take
estrogen. I currently have 3 endocrinologists, the only 3 in this area. One
actually gave me a 1mg estradiol tablet prescription, but that is not what
I wanted. He didn't even ask about the uterus. He didn't even listen to me
when I asked about bioidentical estrogen. I still have a cervix so I think
I am supposed to take progesterone with estrogen. The other two (who are
more competent) are firmly against it. I think I would be more comfortable
with evaluations by other specialists. Unfortunately, the cardiologists
here are so busy that so far I haven't been able to see one. So far, every
time I ask for a referral, I don't get one. I can see a gynecologist. My
PCP asked me to sign a release to one of my endos in response to my
estrogen request. I will see him in 2 weeks to find out what he thinks.

Thanks so much @mayblin for your input. I always appreciate what you write
on the Mayo thread.
Sue

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Same reactions here from docs. I think until the FDA takes the black box warning off we may continue to get these responses. One rheumatologist said these recommendations came to them from professional organizations who looked at all the available studies so "we're not going to make that decision in this room."

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