Reduce dose of exemestane

Posted by jchato9 @jchato9, Nov 4, 2024

After 3 months of debilitating joint pain with exemestane, I was told to try another AI. I don’t believe it will be better. So I researched if different dosage could be as effective and I found that research: Alternative Dosing of Exemestane Before Surgery in Treating Postmenopausal Patients With Stage 0-II Estrogen Positive Breast Cancer . : Conclusions and Relevance: In this randomized clinical trial, exemestane, 25 mg, given 3 times weekly in compliant patients was noninferior to the once-daily dosage in decreasing serum estradiol. - I am going to try this instead of stopping completely AI

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peggydobbs | @peggydobbs | 16 hours ago

I saw a new medical oncologist today, about a big increase in tinnitus after starting first, Letrozole, then switching to Exemestane. Doc recommended either cutting Exemestane tablets in half or taking one every other day. The tablets are tiny (1/8 inch) so I'm going to try the alternate day method. I hope my tinnitus reduces.
Has anyone else had an increase in tinnitus on AIs?

katgob | @katgob | 15 hours ago

I have heard many people have troubles with AIs. I am not one of them. Sounds like the right thing to do to see if you can stop or cut down the tinnitus. Our bodies react so differently to meds.

katrii | @katrii | 13 hours ago

My tinnitus is caused by 7 yrs ago, an autoimmune sudden loss of hearing on L side. Letrozole made everything worse! Exemestane, every other day is so different/tolerable. Tinnitus the same. I’m trying to keep positive attitude and soldier through it.

katgob | @katgob | 12 hours ago

Geez. I wish your dr could find an answer. Hopefully someone with this issue will post or one of the moderators will have some links.
Did you go to the search bar and put tinnitus?

peggydobbs | @peggydobbs | 1 hour ago

In reply to @katrii "My tinnitus is caused by 7 yrs ago, an autoimmune sudden loss of hearing on L..." + (show)

I'm very relieved to hear that someone else had exactly my experience of a great increase in tinnitus with Letrozole. I switched to Exemestane daily, and my tinnitus decreased a little but not back to its usual level. I'll see Exemestane every other day helps. It definitely helped to see a different medical oncologist. The new medical oncologist even does research into AI dosing. So glad I made the change.