Did prostate cancer treatment lower your white cell blood count?

Posted by pattyp46 @pattyp46, Jan 9 6:15am

I, subsequent to very recent radiation and hormone therapy for localized prostate cancer, visited my internist for annual comprehensive bloodwork and physical. During this visit, he advised that my white blood cell counts were quite low, well below “low minimum”. He was aware of my PC therapy.
I think it’s pretty obvious that this would open me up to troubles with any type infections as these cells provide first defense against same.
Shouldn’t this have been made clear to me as a likely consequence of treatment? I guess I’m just surprised as it’s not in much of the literature. It was brought up on this board but nothing discussed since 2023, so…….

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

What drugs are you taking? Many of the drugs we take do inform you that they affect your blood counts. My combo gives me low RBC but normal WBC. Hemocrit very low. And I am on Nubeqa and it specifically says that one of the serious side effects is low white blood cell count, not me, weird.

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Orgovyx is the only drug I take for this.

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@pattyp46

Orgovyx is the only drug I take for this.

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Orgovyxh affect your hemoglobin is it low as well?

Green tea is supposed to help increase your white blood cell count, have you tried that?

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It’s really amazing to me to read all the posts about prostate cancer. When I was first diagnosed I was probably 52 years old and my Dr said that my blood work was that of a 30 year old with the exception of my PSA which he said was slightly elevated. He told me not to worry about it and we will check it next year with my physical. This went on for about 6 years with no check of PSA and it fell by the wayside. I changed Doctors and had a physical and asked for a PSA test and my new Dr informed me that I should have a Urologist evaluation. He scheduled a biopsy and nothing was found. He told me with the number that my PSA was at not to worry I could probably live another 20 years. I moved from Alaska to Reno Nevada and decided to find another Urologist and he did another biopsy to no avail. 5 years later fate would have it I was back in Alaska and had 2 more biopsy’s the last one finding the cancer but almost killed me because of a infection. Back then there wasn’t much to talk about, they didn’t offer any advice to what would happen just that there was only about 3 ways to attack the cancer. One remove prostate, two radiation treatments, three seed implants with radiation therapy. I was never told what was the outcome of the procedures. So I opted for seeds and radiation therapy. That takes me back to 13yrs ago. I’m 77 now and have gone through hell fighting the loss of being a man. The anxiety has been the worst. I’m finally on the right track after 13yrs of experiencing everything that was available. One thing I learned was use it or loose it. I’m on quad mix shots, penis pump used 5 times a week for 3min at a time. My penis goes limp when I lay down even with a ring on, the only way it works is standing up. There’s some pain and discomfort but the outcome is way worth it. I hope this helps anyone going through this process

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Neupogen is a medication that is used to increase the number of white blood cells.
https://www.drugs.com/neupogen.html

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I, too, have had low blood counts after radiation in conjunction with ADT after RP. I was told that ADT (Zytiga and Eligard in my case) also contributes to low WBC and RBC. My medical oncologist was not particularly concerned as other parts of my immune system have had good numbers. About 18 months into the ADT, WBC improved but dropped again in my first 3-month check post-ADT completion. We'll keep watching it, but neither of my medical oncologists (one from Memorial Sloan Kettering) seems worried.

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For reference, here are related discussions:
- Low white blood cell count: Can cancer treatment cause leukopenia https://connect.mayoclinic.org/discussion/low-wbc/

- Treatment Orgovyx, Zytiga and radiation: Question about WBC counts https://connect.mayoclinic.org/discussion/2-months-on-orgovyx-and-zytiga-60-through-radiation/

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Interesting question. I’m going on two years in May since ending treatment.
I had high beam Proton radiation and 3 hormone killing shots. Overall, doing ok but there is so much they don’t tell you. Yes, on my last bloodwork, being treated for an unrelated issue, carpel tunnel, when I was looking over my results, now that most Healthcare system use online sites, because they usually send the same paperwork to the Dr, I noticed that my white blood count was low. I’ve asked my PCP and oncologist PA and they agreed but did not seem concerned. I looked into it online and started taking a supplement, I don’t recall which and try that. It adds up because while I feel ok, I don’t feel great. Two years out and my testosterone is still low as well. So much isn’t told and we have to find out second hand. Not to mention other side effects that may pop up years later. What a journey. Stay strong Brothers.

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I have had my white blood cells at or under the lowest target range for at least the 7 years I have been treated with surgery, 2 radiation programs, and 2 ADT treatments (2 years, then later for 18 months). No doctor has ever seemed concerned. I never get sick (except for advanced PC!), so I don’t mind. But the data helps me to know why. In general, studies show greater longevity with lower versus higher white blood cells.

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