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Transdermal HRT

Osteoporosis & Bone Health | Last Active: 58 minutes ago | Replies (195)

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@mayblin

I just realized and wanted to add some more info. You probably know that micronized progesterone is added to the mix of E2 for those who still have a uterus to minimized the risk of uterine lining hyperplasia. Your obgyn would know if you need progeterone in your case.

This link which @gently provided is very useful in that it's a compilation of users' data for women older than 65:
https://journals.lww.com/menopausejournal/fulltext/2024/05000/use_of_menopausal_hormone_therapy_beyond_age_65.3.aspx
Table 3 and 4 summarized risk reduction or increase based on:
Estrogen alone
Estrogen + progestin
Estrogen + progesterone
Then by type of Estrogen, route and dose.

If one uses E2 alone, the adjusted hazard ratio looks very favorable in many risk categories. Hope these info are somewhat useful to you also if you haven't read them.

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Replies to "I just realized and wanted to add some more info. You probably know that micronized progesterone..."

Thanks so much @mayblin. This is very helpful information!

SO helpful. Thank you so much!

This is so helpful! Any studies on using MHT and vaginal estradiol at the same time?