Anyone taken Evenity (romosozumab) for Osteoporosis?

Are you doing well? Did you finish all 12?

Did you do all 12 injections?

Have you done the 12 months of Evenity now?

I use the nasal spray and have had no issues at all. The pain in my knee is gone. Not sure if that's coincidence.

Hello,
I just had my first dose of Evenity in the back of my arms. I am feeling very nervous and after rereading all the side effects I am grateful to have found this Mayo Clinic conversation site. My imagination and anxiety cause the most trouble for me it seems. Thank you for sharing your experiences.

I’m 50 years old, premenopausal, diagnosed with osteoporosis, t-score of -3.5. I’ve had 2 Evenity shots. After the 2nd one I reacted with racing heart, near fainting, hyperventilating and tingling hands and feet for at least an hour. The drug rep and my doctor decided not to continue my treatment with Evenity. I don’t know where to go from here. What treatment did you decide on? You’re one of the youngest I’ve read about with advanced OP. It’s such a big decision to make at this age because we have the rest of our lives of treatment to face.

lovecg,
low estrogen is what causes low bone mass for most of us. Because you may have a treatable cause, it would be worthwhile to have testing to rule out causes. Have you seen a endocrinologist?
With a -3.5 t-score provided you don't have parathyroid disease, I'd take two years of Forteo or Tymlos. These two drugs give you the strongest most integrated bone. Beyond two years can take a bisphosphonate for a year and take another two years of Forteo, or Tymlos off label. There may be newer, even better treatments by then.
It is interesting that you didn't have an intense response after the first injection.

I haven’t posted on here since. I can’t give you advice one way or the other but I can tell you my experience, so far. I turned 47 4 days before my 12th and final Evinity. I had AV-node tachycardia and an AV-node ablation at 17 years old but have always suffered high heart-rate. I also had 2 suspected TIA’s in my 30’s so I put off Evenity in fear for heart attack or stroke but found myself with few options. After my 2nd Evenity treatment, I was experiencing similar symptoms… racing heart rate and tingling arms and thighs. It turned out it was a drop in calcium and magnesium. With my primary’s advice, I up’d the calcium, staggered throughout the day, and every few days I did a magnesium-flake foot soak and kept on with the Evenity. My pre-Evenity T-score in my spine was -4.3 in 2021 and -4.1 in 2023. I had my last shots in Dec 2024 and my Jan ‘25 Dexa showed -2.5. Meanwhile, I had gotten hooked up with a top-notch endocrinologist in Boston. When I met with him a few weeks ago, he was very skeptical about the Dexa results. He has treated many patients and never seen a gain more than 15-16%. I had to get him the actual Dexa images and am still awaiting his verdict as to whether or not those are real gains. What I can tell you is, aside from the exhaustion and brain-fog from the Evenity, after the increased calcium and the magnesium-flake foot soaks, the rest was easy and I definitely feel a difference, not just in my lower back, but my femurs and lower arms, for sure. Also, about halfway the the treatment, I found out my cousin (in R.I.) actually worked on the quality assurance piece of the Evenity manufacturing line for Amgen. This brought me a great deal of comfort, as well. I planned to post here after I get confirmation from my endocrinologist on what he thinks of the results but, after seeing your post, I wanted to respond sooner. Also, I should note that my primary encouraged me to do squats and add weight where I could when doing routine exercises. Additionally, my Dexa saw no gain in my femoral neck. It was -3.0 before and -3.0 after.

@auntievintage. May your results hold true! I look forward to your good news confirmation.
I am heading into #9. My only concern is the femoral neck
Results. That is my main issue.
Well, onward and upward!🙏