Here in Australia. I took the first injection in July 2023..second in August 23 n last in September..wach 6 weeks apart. Till date Jan 24 I am 70% better. Of course I also do Exercise every day by Physio, Youtube. I also take Collagen, Fish Oil and Ayurvedic ( Natural) anti inflammatory tablets daily..nothing better than your own knees if u are not in excruciating pain. This works for me. I went to a Sports Doctor Specialist., who guarantees I can manage tll 80cyears. After that NEW non surgical treatments are in Trial stages to avoid TKR..Research them in Google. Stringly advice to Check it out. This works for me. I am 75 years old.