@floyd81 Welcome to Mayo Clinic Connect. You mentioned that your kidney function got worse after starting Eliquis. Has your doctor indicated you will be taking this for a long time, or is it short duration? Do you have pre-existing kidney issues, and if so, what was your kidney function before? It is imperative that your doctor be aware of all supplements you take [both over-the-counter and prescription] when prescribing a new medication. In addition, if you have changed your diet or activity level, those should be taken into consideration. At the very least, ask your doctor about the change you noticed, and get a professional opinion for the differences you are seeing.

Usually, the idea is to watch kidney function as a trend, rather than relying on a single test result. Your hydration level, activity level, how you are feeling that day, can all affect the lab results for any given set of bloodwork. How are you feeling today?
Ginger