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Signatera CT DNA Test: What numbers have you seen on your tests?

Posted by gamaryanne @gamaryanne, Dec 10, 2024

We do this test periodically (I was diagnosed 11/2021).

What type of numbers have you seen return on your tests? I don’t know if the scale on the results chart is designed based on my range or the bandwidth of the trial. I hope this makes sense.

Just trying to understand the range since it gives negative or positive Vs the CA19-9 test with a normal “range”.

Interested in more discussions like this? Go to the Pancreatic Cancer Support Group.

markymarkfl | @markymarkfl | Jan 7 11:08am
In reply to @jwg19822005 "This is all really interesting and helpful to read. I asked my mom’s oncologist about Signatera..." + (show)
@jwg19822005

This is all really interesting and helpful to read. I asked my mom’s oncologist about Signatera testing and he said they haven’t adopted it for use yet due to unclear benefit (Cleveland Clinic). My mom has always had lower Ca19-9 levels anyway (219 at diagnosis, was always 3-6 for 4 years after distal surgery, just had a recurrence limited to the ovaries and it went up to 12, waiting to see what it is now that her ovaries were removed) so it sounds like ctDNA may not be accurate for her anyway since Ca19-9 has consistently been low?

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> "it sounds like ctDNA may not be accurate for her anyway since Ca19-9 has consistently been low?"

That sounds logical and seems to fit my (and Amy's mom's) pattern, but I have no data or qualifications to generalize that to other patients or cases.

> "they haven’t adopted it for use yet due to unclear benefit"

I've had it rejected by insurance as "medically unnecessary" several times, but my hospital has always found some way to get it reimbursed.

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