This is all really interesting and helpful to read. I asked my mom’s oncologist about Signatera testing and he said they haven’t adopted it for use yet due to unclear benefit (Cleveland Clinic). My mom has always had lower Ca19-9 levels anyway (219 at diagnosis, was always 3-6 for 4 years after distal surgery, just had a recurrence limited to the ovaries and it went up to 12, waiting to see what it is now that her ovaries were removed) so it sounds like ctDNA may not be accurate for her anyway since Ca19-9 has consistently been low?