I was on the Big 3 (7 days a week) for 13 months and inhaled Amikacin (3 times a week) for 8 months with all Negative sputum samples for MAC and Fungus that entire time. My 6 month CT showed a new cavity and after a Bronchoscopy I had Aspergillus and Abscessus. I was so discouraged but I am now being treated for the Aspergillus only with Voriconazole for 6 months. I finally finish that treatment next month but don't have another CT until May when I go back to NJH. I have never felt sick really except for a little coughing.