Anyone taking Apalutamide and Lupron for more than three years

Apalutamide and Firmagon/Orgovyx in my case (3 years, 3 months). Initially I experienced a lot of fatigue in addition to the hot flushes (never brain fog, fortunately) — I can't say for sure how much of the fatigue was due to the hormone treatments and how much was due to my recovery from paraplegia caused by the tumour on my spine.

The hot flushes are still with me sometimes (but not as frequent or severe), and I'll probably never work full time again, but otherwise, I feel that I'm living a pretty normal life. Moving from Firmagon to Orgovyx as soon as the latter became available in Canada made a big difference: getting a megadose of Firmagon by injection every month was a lot tougher than having it spread out in tiny doses via a daily Orgovyx tablet.

Thanks, this is my 2nd battle with this disease, I have 2 tumors on my spine and pet scan shows everywhere except cranium. I have hot flashes but major complaints are bone, joint, and muscle pain. More so in the cold weather, but PSA has stayed at .1 for over 3 years

I was on Lupron for seven years and then Orgovyx for one year. I was on Zytiga for 2.5 of those years and Darolutamide for 1.5 years. Darolutamide has fewer Side effects then apalutamide, and pretty much works the same.

Hot flashes were real bad on Lupron but worse with Zytiga. Not so bad with Darolutamide. I never had much fatigue. My muscles deteriorated badly and I now go to the gym three days a week to rebuild them. I take bone strengtheners to keep my bones strong, Something very important with these drugs. Brain fog becomes a real problem, you just have to work around it and sometimes you just can’t say anything at all Because the right words don’t come to you.

Get A a lot of exercise to reduce the fatigue, And keep your muscles up. There are resolutions For the hot flashes, If they are real problem, let us know and we can help. The brain fog is lessened with Darolutamide, but lupron affects it negatively, it’s a long-term problem.

Thanks for the info, I try to exercise as much as I can- mostly walking but I have on and off sciatica and I need a knee replacement but I have been told I am a bad candidate

I don't like chlorine personally, but when I was struggling to get out of the wheelchair and experiencing a lot of pain (especially in the ankles and knees) when I tried to bear weight, my physiotherapist told me that there are exercise programmes where the treadmill is underwater in a swimming pool, so that you don't get the strain on your joints. It might be worth looking around to see if there's anything like that in your community.

Thanks for the good info