Trimix injection good or bad idea?

Had RP back in Feb 2024, 56 yrs. Have been using Trimix since July as Cialis did nothing for my ED. Started with the “standard strength mix” that was not as effective as the Dr. said if I went beyond 50 units he would change the prescription to the “higher strength” this has been working much better since August as it only takes 10 unit shots. The question is my erection although it does not stay hard for more than 1 hr., my penis is sore for several hours. As well it’s somewhat painful for days after. Is this normal? All of the readings and articles mention possible infections, scaring and even at times allergic reaction. Is this my issue or is it normal part of the medication use and the marketers are downplaying the discomfort side effects. This is not an issue of mis-injection site as well I switch sides every time and keep a log. Welcome the response of actual users of Trimix!

Had RP back in Feb 2024, 56 yrs. Have been using Trimix since July as Cialis did nothing for my ED. Started with the “standard strength mix” that was not as effective as the Dr. said if I went beyond 50 units he would change the prescription to the “higher strength” this has been working much better since August as it only takes 10 unit shots. The question is my erection although it does not stay hard for more than 1 hr., my penis is sore for several hours. As well it’s somewhat painful for days after. Is this normal? All of the readings and articles mention possible infections, scaring and even at times allergic reaction. Is this my issue or is it normal part of the medication use and the marketers are downplaying the discomfort side effects. This is not an issue of mis-injection site as well I switch sides every time and keep a log. Welcome the response of actual users of Trimix!

My assumption [was] that because an engorged penis is a numb penis, the soreness was due to insenitivity during engorgement to abrasion, bending, etc. In any case I definitely experienced soreness in the hours afterward as well as sometimes longer term. I was using a much lower dosage, so I don't think it is dosage dependent, although perhaps a less hard penis translates to less soreness later. I tailored dosage, as I understood to be the goal, to be sufficient for intimacy but not too much extra. I tracked this by noting time to 1/2 engorgement. If time to 1/2 engorgement was greater than 90 minutes, I took ephenedrine and lowered the subsequent dose. If it was under 45 minutes, I increased subsequent dosage.
While it is true alprostadil (I think that's the one of the tri) deteriorates, it's about 20% in 6 months under consistent refrigeration, so that can be adjusted for fairly easily, and good needle and storage hygiene left me with little concern about contamination so I felt comfortable ignoring the compounding pharmacy's "1 month" shelf life.
Ultimately Vacuum erection device (pump) was also helpful, I was finally able to develop tolerance to the PDE5 inhibitors, and my wife objected to the erection without stimulation, as it felt "urgent" and artificial, so we have left the trimix life behind for a softer, but more satisfying approach. (Marginally enough engorgement for some penetration.) I'm thankful trimix was an option and I will use it again if we feel it would be our best option, but I'm okay with where we are now.
A key element for me is that there is no direct correlation (in my case and based on what I read) between engorgement and orgasm, in spite of my many decades of experiential association.

Not sure what you mean by #8 vs. #9 interesting to read that one of the meds can be cause discomfort. Will be reaching out to my urologist PE
to discuss the issue as he can direct the compounding pharmacy on the mix for a new batch. Hopefully they will have the meds as the last time they sold me a vial that they had not mixed directly for me. Hopefully the next mix works without the long term side effects.

Thank you for your response. Keeping the logs as well but not to such detail. Had tried the pump at first after the PR but it had not worked to any satisfaction to either one of us. Perhaps a more medical grade model and accessories may help if we were to try that route again. The current type of Trimix I’m using is one the compounding pharmacy sourced elsewhere as they were out of stock and could not mix their own last time I purchased it from them. As the previous version the side effect were less severe and good results.

I too have experienced several hours of discomfort following Trimix use. It got worse when I changed from Trimix #8 to #9. It is known that the Alprostadil component of the mixture can cause achiness in 20% of men. Alternatives are low-Alprostadil Trimix and Bimix. I am awaiting a prescription from my urologist for one of these alternative compounds, so I cannot yet speak to their effectiveness.