Yes, the whole thing is difficult. More difficult than my pulmonologist has led me to believe, anyway. I had trouble with Rifampin early on. Chills and tremors. Doctor stopped it for two weeks and then reintroduced it slowly. I'm better except for the coughing (especially after I get out of bed) and the fatigue. That said, I've been feeling a little off lately. Never thought that it might be anxiety owing to the meds. I'll have to be more aware.