Mayo Clinic teaches moderation which is going to be different for each of us. You need to find that 'line' to not step over from mental and/or physical exertion. I also have proven to myself over and over that a good nights rest as measured by Apple Watch is key. My Apple Watch tells me bad nights sleep, good nights sleep, great nights sleep, and more. I can attribute my sleep performance to behaviors of eating amount, eating timing, alcohol consumption, other suspicions and adjust accordingly. For a while I was paying attention to Apple Health features called "Active Energy" and "Physical Effort" as a means of finding my 'line'. One thing for sure is I know when I haven't behaved. I experience PEM and Brain Fog for several days until I recover. So my main countermeasures are knowing my 'line' and a daily power nap not to exceed 30 minutes. Apple Watch and Apple Health aren't the only game in town for technology that can help, it just happens to be what I use.