Contacted my compounding pharmacy regarding the discomfort experienced from the last trimix I had purchased, the pharmacist suggested a lower mix of the Alprostadil. Since the last version had 50 mcg and they offer a version with 25 mcg vs the initial mix that had a 6 mcg that was not as effective. At this point it's all about finding the right trimix formula that delivers the desired results with less side effects. the link to the trimix article was very informative as it allowed me to better communicate with the pharmacist on the formula concentrations, as at least this pharmacy does not use a numbers scheme #8 vs. #9 etc.