@leindabedford1 Welcome to Mayo Clinic Connect. Have you been diagnosed with an IgA issue? What has your doctor said about protein in your urine? Here is what Wikipedia has to say about this gene: https://en.wikipedia.org/wiki/Immunoglobulin_A
Ginger

My husband has IgA. He was not diagnosed until he was 42 which from our understanding is later in life than most end up getting diagnosed. He was already end-stage renal failure by the time we caught it. The only way to diagnose it is through a kidney biopsy. We both had severe covid in early 2020. His nephrologist thinks (not 100% confirmed, just a theory) is that the strong immune response from covid kicked his immune system into high gear causing the IgA to "flare up" and do its final number on his remaining kidney function. If we look back over the years we can see there were signs of kidney decline but really we did not see it for it was until he was in end-stage and the high blood pressure symptoms caused him to go to the doctor. There are DNA tests that can show if you are a carrier of IgA but the only diagnostic tool is a biopsy.