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← Return to Gleason 7 (4+3) radiation, but ADT also? Over treatment?
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Gleason 7 (4+3) radiation, but ADT also? Over treatment?
Prostate Cancer | Last Active: 1 day ago | Replies (65)Comment receiving replies
I would have done the same thing that you did, heavyphil. Six months of ADT is a small price to pay for the extra assurance. Now, if the doctor had said 18 months, I would have said, no. I think the longest I'd want to be on ADT—even if I had aggressive pc—is nine to 12 months to preserve long-term quality of life.
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Completely respect your view. However, age and co-morbity is a factor here. I shall be 80 in August and that for me is key. Recent research has shown that side effects ( let alone double side effects from combined treatment ) added to comorbidity issues and existing conditions have an added effect at this age. For instance, key side effects of ADT including bone and muscle loss (fractures/falls), memory loss/cognitive issues, cardio-vascular problems ( I have controlled high blood pressure) all exacerbate likely pre-existing age-related problems. Advances in modern radiation accuracy and dose escalation have narrowed the margin of improvement conferred by ADT and at this age raise questions of balance relating to quality of life. Recent research bears this out. I am prevented from posting links as a new subscriber but do have a search for:-
'Risk of Death in Octogenarians with Intermediate Risk Prostate Cancer Who are Treated with Radiation Therapy (RT) Plus Androgen Therapy (ADT) Versus Radiation Alone, and NCBD Analysis ( Vol.20 - Issue 2, Supplementr E526-527, October 01, 2024.
'Dose-Escalated Radiotherapy Alone or in Combination With Short-Term Androgen Deprivation for Intermediate-Risk Prostate Cancer:
Results of a Phase 111 Multi-Institutional Trial' - Journal of Clinical Oncology
April 27, 2020
Regards,
David