YES, that's part of my regimen daily. I take 2000mg D-Mannose twice a day, first with lots of water before coffee, the weaker the better or just drink more water first, It doesn't exactly flush toxins, it is a safe sugar that coats the bladder making it nearly impervious to bacteria. BUT that is not enough for me. Look up Methenamine. I take one in morning after breakfast and one at bedtime. It's not exactly an antibiotic; you could think of it as a sanitizer against bacteria. Either way, it has worked for me for 10 months now, with only one infection UTI after a long place trip when I likely did not drink enough water. I also have cut down diet coke to one small glass a day with ice to dilute it, and drink no lattes, no alcohol. Twice I had a glass of wine but only after plenty of water. You just have to find a urologist who is familiar with the new protocols, and they ask you to go through some other attempts of treatment before using this one which I use. Keep records of dates of infections. Good luck !!!