Neuropathy associated with Mounjaro use

I take 7.5% Mounjaro & have had no noticeable increase in neuropathy pain. I’m doing well since I had a NevroHFX spinal cord stimulator implanted and supplement that with intramuscular injections of ALA, 1cc/25mg. 1 -2 times/week.

https://amp.abc.net.au/article/103654198
There are other articles on it
Tingling in hands and feet side effect
Basically if you read the drug insert it does not out right say neuropathy
Gastroparesis side effect of neuropathy, when you start reading tingling hands and feet normally referring to neuropathy
https://www.healthcentral.com/condition/type-2-diabetes/mounjaro-side-effects

Yes! Half my body has gone numb! I was hospitalized no answers. Forgot to take it on scheduled day numbness started receding. It didn’t click that’s what it was. I took the shot and the numbness was worse than ever stop taking it and I’m just going away but not gone. My right hand is incredibly bad and I’m an artist so this is really bad.

I'm sorry to hear about your reaction to Mounjaro. I ultimately found that my increased pain in the right lower extremity is associated with some acute on chronic changes in the lumber/sacral spine. If you haven't thought about it, please report your issue with Mounjaro to the drug makers, your pharmacy, the local diabetic and weight loss clinics, your health provider, and your local health department. I'm under the impression that one of the local diabetic centers in my area has had neurologic issues with Mounjaro, also. I wish you a return to better health in the new year!

I have had neuropathy in my feet for 15 years and both feet and are mostly numb. I started taking Mounjaro 10 months ago and I actually have noticed the numbness is subsiding. I have feeling in both feet. Only hope it gets better because my balance is still not good.

I found one case study reporting neuropathy from semaglutide, but that's it: https://pubmed.ncbi.nlm.nih.gov/39072425/. Doesn't mean it can't happen, but it would certainly be unexpected. My neuropathy started when I was ramping up on tirzepatide (zepbound) this summer, but I'm pretty sure that was coincidence rather than causation -- still working through the diagnostic process. Switching from tirzepatide to semaglutide next week, so it will be interesting to see if it has any impact. In my case, I suspect the neuropathy has been essentially latent for many years during which I've taken a ton of neurologically-active drugs for migraines, and emerged when I shifted to a multivitamin with a triggeringly-high dose of vitamin B6 (which happened at the same time as the tirzepatide ramp-up), and may or may not be being helped or hurt by the GLP-1RA at this point. But it's just the guess of someone who is not medically trained, so who knows?

Your information is very helpful! Thank you.

Here is the link to the FDA system - Medwatch: https://www.fda.gov/safety/medical-product-safety-information/medwatch-forms-fda-safety-reporting

i have had diabetic neuropathy for probably 20+ years. i’ve done all the meds nothing ever helped at all. i’ve been on morphine for a long long time. it seems to make it tolerable. i did start using mounjaro march 10th at 2.5 and it worked really well good after awhile i changed it to 5.0. then 7.5 now back to 5.0 at christmas this year was down a total of 60 lbs. went from 232 march 10th to 170 i was really hoping that would make my feet hurt less. but i can’t tell that it helped. but i’m sure it has to be better as im a lot smaller now. good luck

In theory there should be less to hurt, but very little of the lost weight came from your feet. In my case numb feet and screwed up lower legs from neuropathy and CVI probably aggravate an existing lower back condition. Walking can get physically disabling in a hurry.