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Onward with durable remission

Prostate Cancer | Last Active: Jan 2 8:02pm | Replies (37)

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@rocky999

Thankyou for the replies! Michael Charles your point about us having specific profiles is well put. My persistent PSA 3 mos after RP was 0.31. Although it felt like playing high stakes poker I waited a month to see if it would rise to 0.5 so I could get a PSMA scan. It went up to 0.39 after a month and I was nervous about waiting longer so then I pulled the trigger on ADT and 37 radiation sessions. The presumption was that it was in the prostate fossa area since I had a PSMA scan prior to the RP and it only showed PC in the prostate. Also the post op pathology showed clear margins and no lymph node involvement.Fingers firmly crossed that this presumption was correct.

A couple of other points about the center of excellence second opinion were,firstly , they reran my pathology and restated my staging without seminal vesicle invasion since they observed that it was intracapsular. They also are rerunning my hereditary panel saying that sometimes results from outside companies can be off the mark(!). Finally their research are running germline analysis of my prostatectomy samples. This puts me in their database for trials etc.Their
thoroughness was impressive.

I do appreciate that my health provider med oncologist agreed to monthly PSA/T/blood panel testing. I am curious what the curve for my T return looks like post 6 months of Lupron. Some studies say that 80% of men return to normal levels with a median of 12 months. That lengthens the relative T deprivation past the 6 months of Lupron but who knows what the curve looks like and how that impacts the PC.
Has anybody else done ADT “holidays”?

Thanks for listening. Des

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Replies to "Thankyou for the replies! Michael Charles your point about us having specific profiles is well put...."

People are getting PSMA pet tests after hitting .2. If you’ve got good size metastasis, they will show up at .43.

After RP My PSA dropped below .1 for 3 1/2 years. No ADT necessary. The fact that yours wouldn’t drop below .31 says that you have metastasis producing PSA Somewhere in your body, Probably The prostate bed, so salvage radiation makes sense.

I know a few people that have gone on ADT holidays. In some cases, It worked just fine, The PSA takes a long time to come back. I know one guy who is a Gleason eight, who ended up lighting up like a Christmas tree on a PSMA pet scan after his second holiday. He’s the leader of a bimonthly advanced prostate cancer chat I go to. Recently a couple of other Gleason 9 guys who talked about their holidays in meetings and mentioned that after the second one their cancer became a much more aggressive, resulting in multiple metastasis.

Metastasis can grow even with an undetectable PSA, Be vigilant.