I've had idiopathic peripheral neuropathy for about 20 years now. First drug I used was Gabapentin. Gradually worked up to maximum daily dose of 3600 mg but it wasn't really giving enough relief to be at all functional. Went to see a different pain specialist and went from Gabapentin to Lyrica. Marginal Improvement but nothing exciting. Then Dr asked if I had tried Duloxetine which is Cymbalta, and I had not. Cymbalta was added to the Lyrica and I felt a significant Improvement. This was back in 2011. Pain has gradually continued to increase or else I have built up an immunity to treatment. My current medications are 600 mg of Lyrica, 90 mg of Cymbalta, 40 mg of oxycodone, 2500 mg of Tylenol and almost constant use of a spinal cord stimulator. Tonight I was looking at pain pumps and Mayo Clinic popped up so thought I would drop into this forum again. I got a prescription for medical marijuana that I never filled because it's not covered by insurance or Medicare now. I think I'm about down to the bottom of the well as far as options go. I've also tried other things over the years that really had no effect for me like acupuncture or a compounded ketamine cream that was made at Mayo Clinic but none of those really did anything. Unfortunately it seems to be hit and miss for what might or might not offer any relief not only from one individual to another but also at different time periods for a single individual. Best wishes that you find something to help