I have been taking clofazimine for almost a year with no problems whatsoever. The light suntanned appearance is really the only side effect, with the occasional person asking if I've been on vacation recently! My ID doctor has had so much success with people clearing on clofazimine (unfortunately, I have not) that despite her high expert level with MAC, she has had only one or two people per year who have had to add Arikayce. (I have been one of those, and have started to have clean AFB cultures, but this has been an addition to azithromycin, rifampin and clofazimine. I had to stop ethambutol due to ocular neuritis.)