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@gamaryanne

Which clinical trial did you participate in at MD Anderson?

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Replies to "Which clinical trial did you participate in at MD Anderson?"

@gamaryanne , it was this one:
https://clinicaltrials.gov/study/NCT05922930
It involved injecting CAR-NK (Natural Killer) cells derived from cord blood stem cells directly into the abdominal (peritoneal) space, targeting cancer cells that express the TROP2 protein. It is open to patients with pancreatic cancer and two types of gynecologic cancers, as long as there was measurable metastasis in the peritoneum.

I was patient #5 in Phase 1. I think they're into (or very near) Phase 2 now. I tried to get some intermediate data from the researchers about how it's been going for the other patients, but they couldn't/wouldn't release any details. Very promising science/technology on paper and in the lab, and also in a previous study treating CLL. I was shocked by the complete lack of response in my case, but fortunate that the SoC GAC chemo is still providing some control.

Other possible trial drugs for me would be those targeting KRAS G12D, CHEK2, ATM/ATR, and CDN-18 if I test positive for that. There are some interesting trials in that space, but travel has become a big constraint for me now that I'm on TPN. 🙁