@bzabeli , I think breaks are fairly common, but longer and/or more common for patients who have been on a particular chemo for longer periods of time. Sometimes the break is for medical reasons (blood counts, neuropathy, unrelated illness, etc) and sometimes just social/personal (vacation, special family event, etc).

It's all very patient-dependent. In my case, having Covid and missing just one of my biweekly GAC treatments showed up (coincidentally?) as higher CA19-9, higher Signatera, and growing tumors on scans, but we recovered lost ground after resuming.

The 4-month break from GAC for my clinical trial was disastrous. 🙁