I just had a biopsy done of my uterus in the dr office and it was very painful even after I took an Ativan and Tylenol. Iam 76 years old and didnt have children either so it was even more difficult to do . My gynecologist offered to have me do this procedure in the OR but I declined as I have had so many operations in the last ten years so I didn’t want to have an other general anesthetic . However if i have to have another biopsy again I think I would do it in the OR as it was too painful . Hope that helps .