First of all, many thanks and my sincere appreciation to all that responded and provided insight and suggestions to my previous questions. I now have to come to peace with what I think is the best approach for me to deal with this thing.

My understanding is that Cribriform cells in prostate cancer are associated with more aggressive tumor behaviour and a higher risk of recurrence compared to other histological patterns. Their presence often correlates with worse outcomes, even in the absence of metastatic disease, as they can indicate a higher likelihood of local invasion and micro-metastasis. The question, then, is how effective is EBRT and Brachytherapy plus Firmagon when cribriform cells are present?