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Polymyalgia Rheumatica (PMR) | Last Active: Dec 22, 2024 | Replies (39)
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Curious, what is LDN? My poor husband can barely walk as he has no energy. He is currently in prednisone and methotrexate. Every time they reduce dosage his inflammation markers go up. Along with that his double is so thin he bleeds at slightest bump. He is also type two diabetic so heals slowly and I’m afraid he’ll end up with serious infection. We are very discouraged. Thank you
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LDN is Low Dose Naltrexone. Full dose naltrexone is used to treat drug or alcohol dependence and has many potential side effects. A usual dose is about 50mg. Low dose naltrexone is about one tenth of that dose, about 4.5mg, and has far fewer side effects.
Low Dose Naltrexone (LDN) has been studied for use with various other conditions including Fibromyalgia (auto-immune) and chronic pain:
"Pain Relief: Effective in managing chronic pain conditions.
Low Side-Effect Profile: Generally milder side effects compared to other pain management medications.
Immune Modulation: Helps in regulating the immune system, beneficial for autoimmune disorders."
https://www.dvcstem.com/post/side-effects-of-low-dose-naltrexone
It's use for Polymyalgia Rheumatica has not been fully researched so it's not yet an approved medication for us, but some people have used it for PMR off-label. If I need to try something to get off prednisone, LDN will be the drug I will push to try ahead of the usual "steroid sparing" drugs that have limited success and more potential side effects.