I had breast cancer 2 years ago and a Bone Marrow Transplant in April of 2024. I had the bone density test taken one year after the previous. I have been on an AI which limits estrogen production. My cancer diagnosis was Estrogen positive. I had my ovaries and fallopian tubes removed too. All of this did make a few numbers on my bone scan move from the low osteopenia diagnosis a year ago. MY BMT medical team gave the OK to the medical oncologist for the Zometa one month ago. I have had one treatment. No side effects of note for me, and no results on if it works until time passes.
For your wife, the reason will have to do with her diagnosis. If she has had treatments, is Estrogen positive, has had a bone scan showing the starts of osteopenia, then i see why they want her to get the treatment.
Some others will post that may have been in her shoes. That is the beauty of Mayo Clinic Connect.