Prolia versus Tymlos for osteoporosis: Why choose one over the other?

Hello @windyshores ,
Today I am in more pain than ever. My old endocrinologist finally agreed stopping Evenity and starting Tymlos. My fear is that Tymlos is giving headaches and I already have them probably from Tramadol ( it could be Evenity too). Did you have a headache while on Tymlos? Suddenly my teeth and jaw bone hurts too. I hope this is not one side effects while on Tymlos. The most I afraid more back pain even I can’t imagine to have more than I have already. I am so lost and afraid to make a mistake going on Tymlos . Besides my doctor wants me to start right away and I been reading that I should wait for two months. It’s very hard to make decision on my own. I need your help and maybe some others want to express opinions. Especially those who used Evenity and Tymlos after. Thank you.

@sunny65 I am so sorry you are in pain. So you have not started Tymlos?

I got a headache on Tymlos in the morning, when I took it at night. I switched to morning shots and had no headaches. Everyone is different. Of course as you know I also did a lower dose after trying a full dose and moved the dose up slowly (the pen has clicks to measure dosing) and never actually took a full dose.

I don't think there is much research on Tymlos after Evenity. The two meds have totally different mechanisms. Some of us have posted about waiting a month or two between Evenity and Reclast (they are both anti-resorptive at that point).

I would ask your doctor if Tymlos a month after your last Evenity is the best timing. I don't think anyone knows as yet. It is possible either one month or two will be okay.

It is hard that we don't have enough research yet. Evenity came out in 2019 and it may take awhile before we know anything for sure. Perhaps your doctor has access to studies that are ongoing.

Hello @windyshores ,
I didn’t start Tymlos yet. I got my Evenity shot this week. I hope that this is the last one. I been working with new doctor on starting Tymlos. He doesn’t have a lot of knowledge about Evenity. My understanding is that he doesn’t prescribe this medication to his patients. I wanted mention to you that I keep going to some therapy and feel much worse after lately. I probably should stop. He does a lot of manual work on my back. I’d like to know when your back pain started improving after you started Tymlos? I just worry that my evenings been so bad lately not sure how I will be injecting myself. I will try my best to handle it. Need to make at least small changes in order to see where this going to take me. Thank you so much for communicating with me.

I hope the PT is not doing manual therapy while you are lying down @sunny65. I can only have massage/manual therapy while sitting up!

Not much is known about Tymlos after Evenity. Usually it is the other way around. Can you get a second opinion? It might be worth a try to do Tymlos. I hope you will let us know if it helps since there is so little research on this.

Tymlos did not cause me pain. That's me and others may have different experiences. For me, it prevented further fractures and therefore further pain. However with 7 spinal fractures that don't "heal" but only stabilize, I can certainly relate to your experience though mine has improved with time, walking, tai chi and judicious use of muscle relaxers Much of my pain is muscle pain triggered by changes in the structure of the spine. Keep us posted!

I’m going to skip a night of tymlos and then start up again on sat am. Still the nausea and hangover type of headache with gerd. Had my MRI, tumor shrinking which I do not think is playing a part in these symptoms!

@arlene1958 if you had a contrast MRI do you think the contrast could be causing symptoms?

My doctor was actually happy with 60mcg of Tymlos (but was even happier with 70mcg!).

Switching to mornings eliminated my headaches, Kind of a mystery how each of us reacts, Hope it helps you!

Never had issues with mri contrast. It has been a month with nausea and headaches! I’m hoping doing days may help. I hope you are doing well belated merry Xmas