← Return to Side effects of Orgovyx (relugolix): Anyone have stomach or GI issues?

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@mark1952

Hello, Ifusilli,
I have been on Orgovyx for 2 1/2 months. I am almost 73. I have had a damaged stomach mucosal layer for years. When I started taking Orgovyx (first thing in the morning with food), I had a distinctive stomach pain, kind of a sharp cramping sensation. It gradually diminished and by about a month or so in it seemed to disappear. Have no hot flashes, weight gain, or extreme fatigue. Biggest side effects are constipation, muscle pain, joint pain, significant weakness, loss of strength, occasional weepiness. Scheduled for another 1 1/2 months. Can't wait to get off it! Hang in there! Best Wishes!

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Replies to "Hello, Ifusilli, I have been on Orgovyx for 2 1/2 months. I am almost 73. I..."

Hello, my name is Keith and I started my cancer prostate cancer journey 3 years ago at the age of 86 in 2022 and I am now 88 in 2025. I had a 1 inch by .5 inch tumor in my prostate and the they did a wait and see and it got out into some lymph nodes close by and in my chest and tubes. Went on a diet of Lupron and Zytiga for a year (with all the side affects) and went to psa zero and after about 6 months started feeling like a man again. This new I could be in trouble again as my testosterone had come back (felt like a man again) and went a got checked and sure enough a new tumor had formed in my prostate and it was in a bad place in the very bottom up against my rectum. Because of the location they could not do radiation therapy with out damaging things and causing bowel and urinary problems.
Today I now start my second round of ADT using Orgovyx (Relugolix). I am very aprehensive because the last ADT (therapy) using Lupron and Zytiga ended up causing me to have Diabetes and Neuropathy and now because of my age I have Osteoporosis and Arthritis in my lower back and my Pancreas went on the blink and caused me to lose 30 lbs. I wish I where in better shape to start ADT again and hope it has not metastasized. I am a very active 88 year old and project oriented and this will really slow me down. I hope that Orgovyx has less side affects then Lupron and Zytiga has they really did a job on me. I like your article has my stomach has become very sensitive to morning food and have to be careful what I eat. They have put me on Prilosec 20 mg morning and 20 mg evening before meals to keep the acid down. I all ready have all the problems the cancer drugs to will cause before I even start. If the Lord wants me he will take me or see me through it again to stay a little longer. I have learned what an amazing chemical factory the body is. It is one of the amazing creations of God.