thank you @gracect for posting that. My husband just started that combination a couple months ago, also stage 4 metastasized. It gives me hope to hear of your husband. He'll have his first scan on the 30th since starting this regimen to see what is happening, but his CA19-9 numbers have gone down to the lowest they've been in a year (still over 300... but they started at over 39000, so definitely better!).