I, too, hope you can tolerate jumping into the deep end of the "Big Three Pool". Like so many others, my doctor started me on typical dosages 3x/wk, after introducing each of the meds one week at a time. Unfortunately, I reacted with tremors, nighttime chills, and fatigue after I began adding the rifampin. He took me off everything for two weeks, and then we started the regimen all over again. He's since increased the ethambutol, and I see more increases in my future. Hopefully, your doctor will do similarly if you have trouble.