The amount of prednisone you take with Zytiga Can be very important. Some people can get along on 5 mg of prednisone other people have extreme fatigue on that amount. Talk to your doctor about raising your prednisone to 10 mg, This is not unusual many people use this amount

I was in a webinar a couple of months ago and a Doctor who has prostate cancer said that the fatigue was just terrible with 5 mg so he went up to 7 1/2 and it helped a lot for him. I’ve been working with someone who has had terrible fatigue issues, and I told him about Increasing his prednisone. He spoke to his doctor and his doctor said start taking 10 mg, That made a major difference in his fatigue problem, He still has a little bit of fatigue, but not nearly what he had before. His doctor never recommended this. Many doctors just don’t know how to resolve the fatigue.

I was On Zytiga For 2 1/2 years. It kept my PSA down, but caused a number of issues with my heart, including high blood pressure and afib events. Keep an eye on your blood pressure. It could go up more than you expect.