Hi Lorrie, I started the three time/week regimen (azithromycin, ethambutol, rifampin) for MAC in Feb 2023 and with no success, moved to the daily regimen around August 2023. A number of months later (still with no success) we added clofazimine. In August 2024, I started Arikayce daily. I lost my voice completely by day 7, stopped the meds for 2 weeks until it came back, then started the 3x/week Arikayce protocol. After just a month of treatment, I had my first MAC negative culture. So don't give up hope.