I, too, have MAC and Bronchiectasis. I am 10 weeks in with treatment for MAC. I started Amikacin (via specialized nebulizer) Azithromycin, Ethambutol, and Rifampin all within the same week. I am much more sick now than I was when I started taking these medications. I have a cough. I completely lost my voice. I have ringing in my ears. I’m so short of breath that I need to use supplemental oxygen 24/7. I wake up with a horrific headache every single day. I have no appetite at all. I have nausea, diarrhea, and dizziness. My provider told me that the side effects will ease as I get further into the treatment. I’m not sure I believe that. I have been this sick since week two except that my voice returned in week 8 and I have had significant weight loss (I am 5’4” tall and have gone from 121 pounds to 97 pounds as of today). I literally feel like I am dying and I’m scared.