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Support For Those Quitting Prolia

Osteoporosis & Bone Health | Last Active: Jan 20 7:30pm | Replies (171)

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@jheieck

I am 70 years old I started on Prolia at 63. I've had 12 injections. I have never had a break either. I do have a risk for osteonecrosis of the jaw because the two implants my dentist installed had to be removed because the bone was pushing up out of the gum on one of the implants. Because of this issue I cannot wean off Prolia by taking reclast because it'll worsen the jaw situation. I really only have one option and that is HRT which my bone health specialist, nurse practitioner, has suggested as an option for me. I have never seen an endocrinologist or a rheumatologist but I have appointments with both in the new year and I'm hoping for some help because I also suffer terribly with osteoarthritis. Not sure if this helps you?

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Replies to "I am 70 years old I started on Prolia at 63. I've had 12 injections. I..."

jheieck, I asked a trusted consultant. His response:

" [F]or patients treated with a potent anti-resorptive drug who may experience ONJ, my first choice is to switch them to an anabolic drug, usually either teriparaide (Forteo) or abaloparatide (Tymlos), in order to help heal the ONJ. However, studies show that taking teripararatide AFTER denosumab (Prolia) can cause temporary bone loss at the spine and hip, and perhaps permanent bone loss at the 100% cortical bone radius shaft.The way I would tend to manage this in a patient on Prolia would be to do conservative management of the ONJ while the patient is awaiting her next injection of Prolia, and plan to treat with teriparatide about when the next injection of Prolia was due. Not to treat her osteoporosis, but rather to help heal her ONJ. It usually heals within a 6-month treatment course. Then transition the patient to the antiresorptive drug of her choice - either oral alendronate sodium, or IV zoledronic acid (neither of which is quite as anti-resorptive as denosumab (Prolia), or transdermal estradiol at a dose of at least 37.5 mg along with micronized progesterone at an oral dose of 100 mg at bedtime."