My best to you with your symptoms. At 69 yrs, I work w/many symptoms f/MS, lupus, Sjogren's, RA. Similar to your eyes, I have had eye plugs, very blurry vision, etc & even w/same meds as you over yrs +Rituxan past 9 yrs every 4 mos. On Methotrexate, I was getting severe headaches over my eyes-similar to my past migraines & discontinued. I find the Sjogren's, itself, has caused most of my eye symptoms. Eye specialist agree w/my choice of over counter eye drops x4 hrs, moist wash cloth on eyes 2-3x's day, plugs, humidifier a must. Tried many drops, always return to Refresh for my best results. I hope you find suggestions from others that may help.