I had toxic levels of B6 with a number of symptoms, taking awhile to diagnose. I did not, however, have any skin issues. GI and PN dominated. It took about 7 months to get B6 back to normal. PN remains. From readings suggested from this group, I have a better understanding of how B6 finds its way to nerve cells, causing damage. I am trying to exercise more, hydrate more and take a multi without B6 to prevent it worsening, as numbers started to inch up again.