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Treatment resistant depression help.

Depression & Anxiety | Last Active: 1 day ago | Replies (26)

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@mcgrathcreative2

Just a word of caution when supplementing antidepressants with antipsychotics. I found the combination to be very helpful with my treatment resistant depression. However I now have permanent Tardive Dyskinesia (weird uncontrolled mouth movements) from using Seroquel and Cymbalta with Wellbutrin. I’m 64 and have struggled with chronic severe migraines which exacerbated my depression and have tried just about everything to help with both conditions. I didn’t even know I had the weird mouth movements until I saw myself on a Zoom recording. I was horrified and immediately got off the antipsychotic but the TD never went away. I’m devastated over this permanent side effect. Be careful.

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@mcgrathcreative2
I am sorry to hear of your TD. I have read about this side effect. Which antipsychotic were you on and at what dose? I am on aripiprazole 2 mg and noticed worsening symptoms at 5 mg so they reduced back to 2 mg. Did you have any signs or symptoms before developing permanent TD?

I was also put on Seroquel as well as Mirtazapine at the same time. I find myself outspoken with no filter and too willing to engage in a physical altercation. My go to for relief is to think about suicide. I am currently only taking diazepam and medicinal cannabis alongside my regular medication for anti-rejection. Everything I have tried to do to address it is a waste of time, I have been down so many roads that all ended up dead ends it is adding to my depression. I could only imagine how you feel developing such a side effect. It makes you feel like a lab test sometimes the way they just try this and that and then these two. Where I am in Australia, we have Voluntary Assisted Dying I tick six out of seven boxes. I have to be diagnosed with seven months to live, this means I can refuse to take anti-rejection medication and qualify in a short time. This is my happy thought as it empowers me in a weird kind of way.