bone pain with fosomax

Thank you for your wishes but again, I ask you for your source of information. How is anyone to believe you especially me with what you are saying. Who are you to advocate another medication for me? I don’t mean to sound mean but i am definitely suspicious!! Why are you not backing up your words with the source?

susanjane77, while I welcome your suspicions, if you reread my post you'll recognize that I am not willing to advocate medication for you.
You don't sound mean, rather you sound honest. If you are more specific with those doubts, I can easily send links that inform my opinion.
Are you wondering about the difference between modeling and remodeling? Are you uncertain as to whether Prolia really causes rebound when you stop taking it, if some really do suffer cascade fractures after Prolia.
If you were undecided, if your provider were offering you a choice that you were struggling to make, or if you were thinking about stopping Prolia, that would make me willing to offer you my opinion.
But you are already on a medication recommended by your physician. So you've begun and without the side effect that convince some that they need to take something else.
Once a person has decided, I have too much respect for their personal agency to breech it.
If you repost asking about a specific doubt, I'll send links without my opinion.
You've made good points and allowed my to express what I find essential to the process at Mayo Connect.

Unsure if I saw this post earlier or responded but as it's so specific to my own experience, will do so now, even though it's already December and I hope by now you feel better. I also took Fosamax for about the same amount of time, 2 -3 months, in 2008 when my right leg also became painful. As you said, too painful to put weight on or walk. I stopped the med and the pain did go away. Over the years, my DEXA scores didn't change much but didn't improve either. My DEXA in 2023 showed decline in my spine and so I made the decision, after lots of research and speaking with friends and family, to give Reclast a try-even though it's in the same class and the pharmacy flagged it when my dr. ordered it. I was afraid of spinal fracture so went ahead. The infusion was late January and went fine though 10 hours later I had severe rib, back and side pain plus a temp and dizziness. I rested and it abated within the day, just tired for a few days afterwards. About 2 months later I began again with the leg pain. It seems to flare up for weeks at a time, go away and then begin again after a couple of months. I have to assume it is the med and will not take it again when due.

susanjane77,
I don't consider the research linked to represent "proof."
I am compelled by research on the way these medications work. The mechanism of action can tell you they type of bone engendered and sketch the reactions they produce in other aspects of our bodies.
"Osteoanabolic compounds are defined by their ability to stimulate bone formation. The formation of new bone can restore, at least partially, degraded bone microarchitecture that is characteristic of osteoporosis and an independent predictor of fracture risk. This bone forming effect cannot be achieved by antiresorptive drugs that decrease bone formation as well as bone resorption."
https://pmc.ncbi.nlm.nih.gov/articles/PMC10118815/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3940980/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9081316/
Some of the articles are fairly dense with information and not readily understood. I wondered about just sending links but that could be daunting.
https://www.fda.gov/safety/medical-product-safety-information/prolia-denosumab-drug-safety-communication-fda-adds-boxed-warning-increased-risk-severe-hypocalcemia
https://academic.oup.com/jcem/article/109/10/e1817/7645059
https://www.sciencedirect.com/science/article/abs/pii/S1297319X24000654

Finding the right medication for you is something that is often discussed in the forum. Working with your healthcare provider and asking questions can help with decision making.

- With all the medication options, why is _____ your first treatment choice for me?
- How long will I take it?
- How do you know it is working?
- What if it stops working?
- What else do I need to know?

Here are a couple of articles from Mayo Clinic that can help.
- Mayo Clinic Q and A: Finding the right osteoporosis medication https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-q-and-a-finding-the-right-osteoporosis-medication/
This article outlines the function of the various medication options available:
- Osteoporosis treatment: Medications can help https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869

@jozer, back to you and your original concern about bone pain. Has the bone pain subsided? What did you learn from your endocrinologist about side effects and options for you?