I had extreme jaw pain and a bone scan that showed osteoradionecrosis. As this is a very rare side effect the other consideration was odontogenic inflammation, but 5 trips to dentist could not find a cause for that. The decision was to not repeat the Prolia. I do have to say that my sister and brother have both been on Prolia after their cancer treatments and have done extremely well with it. So I would definitely not rule it out for others.