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I happen to be on Prolia after 5 years of Reclast. I read what you wrote to @jozer and am curious as to your source of information. I know that i will never be off Prolia as my doctor said so and he explained why I should take it versus the others. So, I am curious as to why Forteo and Tymlos are better than Prolia and again…the proof. Thanks.
Replies to "I happen to be on Prolia after 5 years of Reclast. I read what you wrote..."
susanjane77,
I don't consider the research linked to represent "proof."
I am compelled by research on the way these medications work. The mechanism of action can tell you they type of bone engendered and sketch the reactions they produce in other aspects of our bodies.
"Osteoanabolic compounds are defined by their ability to stimulate bone formation. The formation of new bone can restore, at least partially, degraded bone microarchitecture that is characteristic of osteoporosis and an independent predictor of fracture risk. This bone forming effect cannot be achieved by antiresorptive drugs that decrease bone formation as well as bone resorption."
https://pmc.ncbi.nlm.nih.gov/articles/PMC10118815/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3940980/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9081316/
Some of the articles are fairly dense with information and not readily understood. I wondered about just sending links but that could be daunting.
https://www.fda.gov/safety/medical-product-safety-information/prolia-denosumab-drug-safety-communication-fda-adds-boxed-warning-increased-risk-severe-hypocalcemia
https://academic.oup.com/jcem/article/109/10/e1817/7645059
https://www.sciencedirect.com/science/article/abs/pii/S1297319X24000654
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@susanjane77
Prolia may be a far better medication for you than any other. Your physician knows your medical history and what vulnerabilities to any of these medications engender. Together you have decided on Prolia. I't isn't of value to you for me to try and enter that decision.
If you were (still) choosing between an anabolic and an antiresorptive, I would advocate for the anabolic. I see structural advantage in integrative bone.
As for proof, in all the research--microscopic bone studies, mechanism of action studies, associative studies, the "proof" is patient experience. You will be the proof of Prolia's superior value to your bones.
Bless your choice with the best luck.