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Prolia discontinuation

Osteoporosis & Bone Health | Last Active: 1 day ago | Replies (119)

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@jheieck

Hi I've posted a few times about my dilemma with trying to transition from Prolia to something else due to complications with dental work and possibility of ONJ, but I've never really read the breakdown of what happens during rebound when you go off of Prolia. This is pretty scary given the fact that I have been on Prolia for 6 years, meaning I've had at least 12 injections if not 13. I am due for a Prolia shot end of December early January but I'm waiting to get into the endocrinologist to evaluate my parathyroid activity, which is elevated, and to see what my options are for weaning off Prolia. This doesn't sound to promising to me. Does anyone on the thread know just how long someone can be on Prolia before there are other long-term effects? I'm only 70 years old. What if I stay on Prolia till I croak? That could be another 15 years and 30 more shots?? Why was this medication even put on the market? Certainly wasn't told that people who have extensive dental work should not go on it, not by my doctor... I found out on my own.

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Replies to "Hi I've posted a few times about my dilemma with trying to transition from Prolia to..."

I am just wondering, did you find another option yet? I had 2 Prolia injections and stopped because of a rash that developed , grew and lingered. So now I am on Alendroniate (Fosamax)
and not liking it much. I am 71 y.o. and have similar concerns.

I am in your exact situation. What did you decide?

The trouble is there is no data. Drs and endocrinologist, l think are flying blind. So no studies on which bisphophonate is most effective, how long one has to be on the bisphophonate, or as you mention exactly how many years that we have been on Prolia?? Like you l have asked drs if they have patients who have successfully transitioned and no definite answer.
I agree with you who said why is it still on the market. Here in Australia, l have read AMGEN now have 76% of the market as it seems to have become the Dr's choice. All very distressing for those of us trying to get off it.