Although it lowers your T levels quickly - within 1 month - I felt no side effects until perhaps the end of the second month - mild hot flashes.
They did progress (now in my 5th month) but the worst side effect for me is the insomnia. Never had trouble sleeping and usually fell right back to sleep even after getting up to pee.
Now it’s wide awake, toss and turn….Don’t think a trip - even a few weeks long - will be adversely impacted by Orgovyx but everybody’s different.