Intraductal Prostate Cancer: Any info about recurrence rates?

Posted by biker70 @biker70, Nov 4 4:30am

Anyone on here have intraductal prostate cancer and low Gleason? I was diagnosed this year and had surgery. Gleason 3+4 and clear pathology except intraductal. Doctors just say follow up PSAs which have been thankfully, undetectable. However I am not understanding future reoccurrence rate and which medications/treatments I will need. Anyone on this forum with intraductal?

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

I’m supposed to get a link to the conference itself so people can watch it again. I will post that link here when I get it.’

Here is a link to the place where the conference will be posted. It is part of the journal club. There are a number of other very interesting conferences there already.
https://www.urotoday.com/video-lectures/a-journal-club-for-patients-with-prostate-cancer.html

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@biker70 here’s the invitation I received for the UCSF seminar they discussed problems with intraductal and cribriform.

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How does one reconcile a biopsy core of 4+3 with cribriform present with a low (.40) Decipher score?

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@hiker62

How does one reconcile a biopsy core of 4+3 with cribriform present with a low (.40) Decipher score?

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Follow your PSA monthly. You don’t mention latest PSA or your Gleason score Need to know that and what you’ve had done, what medicine/treatment you’re on now in order to really give opinions. .

I am 4+3 and have had it for 15 years. 4 reoccurrences so far. Still, I have treatments to move to in the future.

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@hiker62

How does one reconcile a biopsy core of 4+3 with cribriform present with a low (.40) Decipher score?

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As @jeffmarc indicates, some of it has to do with the size of the cribiform glands. Are they greater than .25mm? If so, that seems to be a negative feature based on studies. On my pathology, and I think many other people’s, the size of the cribiform glands is not listed. I’m also a 4+3. 10% of my pattern 4 is cribiform, which seems kind of in the middle from what I’ve read. In my case, my uPSA is < 0.006, so that is all that matters for now, 13 months post-surgery. I do know, however, that my recurrence odds are higher because of the cribiform.

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@jeffmarc

Follow your PSA monthly. You don’t mention latest PSA or your Gleason score Need to know that and what you’ve had done, what medicine/treatment you’re on now in order to really give opinions. .

I am 4+3 and have had it for 15 years. 4 reoccurrences so far. Still, I have treatments to move to in the future.

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Gleason is 4+3=7 with crib pattern present (in one core). PSA 4.99. Set for RP in a month. Decipher .40.

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Your numbers do not look too bad, but cribriform Is a problem. It causes the Gleason to actually be more aggressive. Here is a video that discusses cribriform, you might want to watch it, it can give you more information.
https://www.urotoday.com/video-lectures/a-journal-club-for-patients-with-prostate-cancer/video/mediaitem/4452-unfavorable-histology-classification-aims-to-reduce-unnecessary-treatment-journal-club-jesse-mckenney-cornelia-ding.html

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Thanks for the video. Very interesting.

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My path report does not state the size of the cribriform (large or small).

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@hiker62

My path report does not state the size of the cribriform (large or small).

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Speak to your doctor. Ask if the slides can be reviewed again to get the size of the cribriform. They may have to send it to a specialist. Depends on where you’re getting your medical treatment.

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