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@hiker62

How does one reconcile a biopsy core of 4+3 with cribriform present with a low (.40) Decipher score?

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Replies to "How does one reconcile a biopsy core of 4+3 with cribriform present with a low (.40)..."

Follow your PSA monthly. You don’t mention latest PSA or your Gleason score Need to know that and what you’ve had done, what medicine/treatment you’re on now in order to really give opinions. .

I am 4+3 and have had it for 15 years. 4 reoccurrences so far. Still, I have treatments to move to in the future.

As @jeffmarc indicates, some of it has to do with the size of the cribiform glands. Are they greater than .25mm? If so, that seems to be a negative feature based on studies. On my pathology, and I think many other people’s, the size of the cribiform glands is not listed. I’m also a 4+3. 10% of my pattern 4 is cribiform, which seems kind of in the middle from what I’ve read. In my case, my uPSA is < 0.006, so that is all that matters for now, 13 months post-surgery. I do know, however, that my recurrence odds are higher because of the cribiform.